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RMRC No. RMRC23006 Order
Strain/Stock Designation SD-Apoeem1Narl/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing
Last Update Date 2023/4/14
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory rat
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ：
Other Names ：
Background Strain ： SD
Strain Description ：
1.  SD-Apoeem1Narl/Narl mutant rat was generated using CRISPR/Cas9 technology and Apoe gene was  deleted from 2140-2888 bp.
2.  Apoe homozygous knockout rat has higher serum cholesterol and triglyceride comparing to its  heterozygous and wild type littermate.
Depositor ：
Chi-Kuang Leo Wang / 王繼廣
Email ： bujiii@nlac.narl.org.tw
Allele Symbol ： Apoeem1Narl
Allele Name ： endonuclease-mediated mutation 1, National Applied Research Laboratory
Allele Description ：
Strain of Origin ： SD
Gene Symbol ： Apoe
Gene Name ： apolipoprotein E
Chromosome ： 1
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Metabolism Diabetes and Obesity
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： PubMed ID: 35522651

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由NLAC-Narlabs所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NLAC-Narlabs
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email: bujiii@nlac.narl.org.tw
Construct Map ：
 
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