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RMRC No. RMRC13354 Order
Strain/Stock Designation C57BL/6N-Grhl2tm1aNarl/Narl
Status
SP| (Cryopreserved or freeze-dried sperm)
Availability Level4
Pricing International: 1,308USD
Last Update Date 2018/11/23
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1. 
Top priority novel gene in IMPC list and has potential affected in Cardiovascular, Neurobiology Research and Reproductive Biology.
2.  .The targeting construct was electroporated into C57BL/6N embryonic stem (ES) cells.
3.  Construct strategy is similar as knockout-first, promoter-driven in KOMP   (https://www.komp.org/alleles.php), but the exons from ENSMUSE00001251037toENSMUSE00001246353were replaced with frt-flanked LacZ reporter and Neomycin resistant gene and LoxP-flanked cDNA of Grhl2.
4.  Mice homozygous for this mutation may occur embryonic lethality.
Depositor ：
National Laboratory Animal Center, Narlabs / 國家實驗動物中心
Email ： bujiii@nlac.narl.org.tw
Allele Symbol ： Grhl2tm1aNarl
Allele Name ： grainyhead like transcription factor 2, target mutation 1a, National Applied Research Laboratories
Allele Description ：
Strain of Origin ： C57BL/6
Gene Symbol ： Grhl2
Gene Name ： grainyhead like transcription factor 2
Chromosome ： 15
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Cardiovascular Neurobiology Research
Reproductive Biology
Construction Technologies ：
Cre-lox system FLP-FRT system
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ：

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由NLAC-Narlabs所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NLAC-Narlabs
Construct Map ：
 
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