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RMRC No. RMRC13383 Order
Strain/Stock Designation C57BL/6-Ins1em1Narl/Narl
Status
LM| (Live Animal)
Availability Level3
Pricing Academia: 5,730NTD    NSTC: 4,010NTD
Last Update Date 2023/6/27
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6JNarl
Strain Description ：
1. 
This strain is generated with Tryptophan insertion at amino acid position 97 by CRISPR/CAS9 technique.
2.  Mice homozygous were observed hyperglycemia and hyperglycosuria around 4 to 6 weeks of age. Nephropathy also appeared from 20 weeks and became significantly at 44 weeks.
3.  Hyperglycemia was also found in some heterozygous males of 6-8 weeks age but the symptom would be gone around 20 weeks.
Depositor ：
Hsiang-Hsuan Sung / 宋向軒
Email ：
Allele Symbol ： Ins1em1Narl
Allele Name ： Insulin 1, endonuclease-mediated mutation 1, National Applied Research Laboratories
Allele Description ：
Strain of Origin ： C57BL/6JNarl
Gene Symbol ： Ins1
Gene Name ： Insulin 1
Chromosome ： 19
Genotyping Method ：            
Genotyping NLAC ：            
Research Application ：
Internal/ Organ Metabolism
Diabetes and Obesity Endocrine
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x hetero/hemi
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由國家實驗動物中心 所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NLAC-Narlabs
Construct Map ：
 
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