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RMRC No. RMRC13375 Order
Strain/Stock Designation FVB/N-Tg(PGK-miR29a)Wfs/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing
(Embryos)　Industry：*　Academia: 7,066NTD　NSTC: 4,923NTD
(Cryo Recovery)　Industry：*　Academia: 12,618NTD　NSTC: 12,618NTD
Last Update Date 2019/8/20
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TG (Transgenic)
Other Names ：
Background Strain ： FVB/N
Strain Description ：
1. The linear designed construct composed of PGK promoter and MiR-29a precursor full-length sequence was transferred into fertilized eggs from FVB/N mice.
2.  The mice carried transgene reduced diabetes-mediated glomerular hypertrophy and periodic acid-Schiff stain, attenuated diabetes-induced  loss of nephrin and WTand decreased the expression of fibrogenic factors TGF-β1, fibronectin, and IL-1β in diabetic renal glomeruli.(J Am Soc Nephrol 2014,25:1698)
3.  This miR-29a transgenic mice had high bone mineral density, trabecular microarchitecture and cortical thickness. miR-29a overexpression mitigated the glucocorticoid-induced impediment of bone mass, skeletal microstructure integrity and mineralization reaction and attenuated fatty marrow histopathology. (Bone 2015,81:80-88)
4.  It was observed that more than 95% of mice carried this transgene are male.
Depositor ：
Wang, Feng-Sheng / 王逢興
Email ：
Allele Symbol ： Tg(PGK-miR29a)Wfs
Allele Name ： transgenic insertion, Wang, Feng-Sheng
Allele Description ：
Strain of Origin ： FVB/N
Gene Symbol ： Pgk1
Gene Name ： phosphoglycerate kinase 1
Chromosome ： UN
Gene Symbol ： Mir29a
Gene Name ： microRNA 29a
Chromosome ： UN
Genotyping Method ： Download            
Genotyping NLAC ：            
Research Application ：
Apoptosis Immunology and Inflammation
Metabolism Diabetes and Obesity
Genetics Research
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： homo x hetero/hemi
References ：

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： MicroRNA-29a mitigates glucocorticoid induction of bone loss and fatty marrow by rescuing Runx2 acetylation
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由Core Lab. for Phenomics and Diagnostics, CGMH所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Core Lab. for Phenomics and Diagnostics, CGMH
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email:
Construct Map ：
 
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