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RMRC No. RMRC13371 Order
Strain/Stock Designation C57BL/6N-Fat1tm1aNarl/Narl
Status
LM| (Live Animal)
Availability Level3
Pricing D,G
Last Update Date 2019/1/31
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6
Strain Description ：
1.  Top priority novel gene in IMPC list and has potential affected in Cardiovascular, Immunology and Inflammation, and Neurobiology Research.
2.  The targeting construct was electroporated into C57BL/6N embryonic stem (ES) cells.
3.  LacZreporter and a frt-flanked neomycin resistant gene were inserted into intron 6, and exons from ENSMUSE00000608094 to ENSMUSE00000608093 areloxP-flanked.
4.  Neonates died in 2 weeks after birth in homozygotes and the body size of homozygotes is smaller than heterozygotes and wild types.
5.  The information shown on MGI is as follows: Homozygotes for a targeted null mutation exhibit holoprosencephaly, anophthalmia, kidney defects and perinatal lethality. Mice homozygous for a hypomorphic allele exhibit altered shoulder girdle and facial musculature, retinal defects, abnormal inner earpatterning and kidney defects
Depositor ：
National Laboratory Animal Center, National Applied Research Laboratories / 國家實驗動物中心
Email ： bujiii@nlac.narl.org.tw
Allele Symbol ： Fat1tm1aNarl
Allele Name ： FAT atypical cadherin 1,target mutation 1a, National Applied Research Laboratories
Allele Description ：
Strain of Origin ： C57BL/6
Gene Symbol ： Fat1
Gene Name ： FAT atypical cadherin 1
Chromosome ： 8
Genotyping Method ：            
Genotyping NLAC ：            
Research Application ：
Immunology and Inflammation Cardiovascular
Neurobiology Research
Construction Technologies ：
Cre-lox system FLP-FRT system
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： hetero/hemi x wild type
References ： No

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由NLAC-Narlabs所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NLAC-Narlabs
Construct Map ：
 
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