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RMRC No. RMRC13369 Order
Strain/Stock Designation Stock-Foxn1nu Tg(ACTB-flEGFP-DsRedT1)37Klin/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing
(Embryos)　Industry：*　Academia: 7,066NTD　NSTC: 4,923NTD
(Cryo Recovery)　Industry：*　Academia: 12,618NTD　NSTC: 12,618NTD
Last Update Date 2019/8/20
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： MSK (mutant stock),CON (congenic strain)
Mutant Type ： TG (Transgenic)
Other Names ： CALELD Nude
Background Strain ： CAnN.Cg-Foxn1nu/CrlNarl
Strain Description ：
1.  The transgene was designed with loxP-flanked EGFP gene followed by DsRedT1 gene driven by cytomegalovirus (CMV) enhancer, the chicken β-actin promoter. The transgene was microinjected into FVB/N embryos. This strain were crossed with CAnN.Cg-Foxn1nu/CrlNarl for several generations to maintain heterozygous Foxn1nu allele.
2.  This reporter mice could switch from EGFP to DsRed expression by crossed with mice carried cre transgene. Mice expressed tetrameric DsRed protein after cre-induced recombination were further bred to generate homozygotes (DsRed+/+). Whatever heterozygotes or homozygotes were observed heart failure. Homozygous females died at 5 months on average and males died at around 7 months. The lifespan of heterozygotes is longer, on average 12 months for females and 18 months for males
3.  This strain with high level of EGFP expression is free of any cardiovascular symptom and lived for at least 30 months.
Depositor ：
Kurt MC Lin / 林名釗
Email ：
Allele Symbol ： Foxn1nu
Allele Name ： forkhead box N1; nude
Allele Description ：
Allele Symbol ： Tg(ACTB-flEGFP-DsRedT1)37Klin
Allele Name ： transgenic insertion 37, Kurt MC Lin
Strain of Origin ： FVB/N
Gene Symbol ： Foxn1
Gene Name ： forkhead box N1
Chromosome ： 11
Gene Symbol ： Actb
Gene Name ： actin, beta
Chromosome ： UN
Genotyping Method ：            
Genotyping NLAC ：            
Research Application ：
Hematology Cancer
Immunology and Inflammation Cardiovascular
Internal/ Organ Cell and Developmental Biology
Dermatology Genetics Research
Construction Technologies ：
Cre-lox system
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： homo x homo
References ： PubMed ID: 27494843

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應引用下述已發表之論文： Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency Oncotarget, Vol. 7, No.34 p5
Should the use of this material result in one or more scientific
publication(s) the recipient agrees to cite the paper(s)： Cardiac fibrosis in mouse expressing DsRed tetramers involves chronic autophagy and proteasome degradation insufficiency Oncotarget, Vol. 7, No.34 p54274-54289 (PubMed ID: 27494843)
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由 Dr. Kurt MC Lin所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Dr. Kurt MC Lin
分讓申請人向國研院動物中心國家實驗鼠種原庫(NLAC-RMRC)申請本材料時，應附上寄存人簽名之授權分讓同意書作為附件；NLAC- RMRC 在取得寄存人書面同意後，始進行此材料之分讓。
The recipient should obtain a written consent from the depositor of the BIOLOGICAL RESOURCE, prior to NLAC-RMRC accepting the material distribution request.
Depositor Email:
Construct Map ：
 
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