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RMRC No. RMRC13353 Order
Strain/Stock Designation B6.129-Cdk12tm1FmjTrp53em1Fmj/Narl
Status
EM| (Cryopreserved Embryos)
Availability Level4
Pricing
(Embryos) Industry:* Academia: 7,066NTD NSTC: 4,923NTD
(Cryo Recovery) Industry:* Academia: 12,618NTD NSTC: 12,618NTD
Last Update Date 2019/3/26
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species laboratory mouse
Strain Type MSK (mutant stock),CON (congenic strain)
Mutant Type TM (Target Mutation)
Other Names
Background Strain C57BL/6
Strain Description
1. 
Trp53 mutation in this strain is generated by CRISPR/CAS9 technique and microinjection with embryos derived from strain B6.129-Cdk12tm1Fm j/Narl (RMRC13312)
2.  Deletion of Exon 3 to Exon 10 in Trp53 occurs in this strain
3.  Homozygous mutants often develop tumors (lymphomas and sarcomas) since three to six months of age.
4.  The breeding scheme used in this strain is homozygous mutant (Cdk12fl/flTrp53-/-) x homozygous mutant (Cdk12fl/flTrp53-/-).
Depositor
Ming-Ji Fann / 范明基
Email mjfann@ym.edu.tw
Allele Symbol Cdk12tm1Fmj
Allele Name cyclin-dependent kinase 12, target mutation 1, Ming-Ji Fann
Allele Description
Allele Symbol Trp53em1Fmj
Allele Name transformation related protein 53, endonuclease-mediated mutation 1, Ming-Ji Fann
Strain of Origin 129
Gene Symbol Cdk12
Gene Name cyclin-dependent kinase 12
Chromosome 11
Gene Symbol Trp53
Gene Name transformation related protein 53
Chromosome 11
Genotyping Method Download            
Genotyping NLAC            
Research Application
Cancer Cell and Developmental Biology
Construction Technologies
Cre-lox system
Animal Health Reports
Colony Maintenance
Breeding & Husbandry
Colony Maintenance
Mating System
homo x homo
References No

Specific Terms of Use
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果,不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時,應揭露並致謝本材料係由Dr. Ming-Ji Fann 所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge Dr. Ming-Ji Fann
Construct Map
 
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