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RMRC No. RMRC13417 Order
Strain/Stock Designation C57BL/6-Ace2em1(HiBiT,-ACE2)Narl/Narl
Status
SP| (Cryopreserved or freeze-dried sperm)
Availability Level4
Pricing Academia: 21,527NTD    NSTC: 15,069NTD
Last Update Date 2023/9/25
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species ： laboratory mouse
Strain Type ： COI (coisogenic strain),MSR (mutant strain)
Mutant Type ： TM (Target Mutation)
Other Names ：
Background Strain ： C57BL/6JNarl
Strain Description ：
1.  This strain is generated via CRISPR/Cas9 technology. The Ace2em1(HiBiT,-ACE2) was designed with Exon 4 of mouse Ace2 gene was replaced by a HiBit lucifercase and IRES followed by chimeric Ace2 gene. Chimeric Ace2 gene is composed of mouse Ace2 cDNA including N-terminal signal peptide, intracellular domain, transmembrane domain, and human ACE2 cDNA for extracellular domain.
2.  After Covid19 infection, mutants had mild pneumonia symptom in lung. Virus could be detected in lung tissues via PCR.
Depositor ：
National Laboratory Animal Center, National Applied Research Laboratories / 國家實驗動物中心
Email ：
Allele Symbol ： Ace2em1(HiBiT,-ACE2)Narl
Allele Name ： angiotensin converting enzyme 2,endonuclease-mediated mutation 1, National Laboratory Animal Center, National Applied Research Laboratories
Allele Description ：
Strain of Origin ： C57BL/6JNarl
Gene Symbol ： Ace2
Gene Name ： angiotensin converting enzyme 2
Chromosome ： X
Genotyping Method ：            
Genotyping NLAC ：            
Research Application ：
Immunology and Inflammation Genetics Research
Construction Technologies ： No
Animal Health Reports ：
Colony Maintenance
Breeding & Husbandry 		：
Colony Maintenance
Mating System 		： homo x homo
References ：

Specific Terms of Use ：
有特別規定
本生物材料僅限使用於學術研究。寄存者對於分讓申請人使用本材料 所獲得之研究成果，不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE for academic research purpose.
分讓申請人公開發表使用本材料所獲得之論文或其他研究成果時，應揭露並致謝本材料係由NLAC-Narlabs所提供
Should the use of this material result in one or more scientific publication(s) the Recipient Investigator agrees to mention and acknowledge NLAC-Narlabs
Construct Map ：
 
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