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RMRC No. RMRC13288
Strain/Stock Designation NOD.Cg-PrkdcscidIl2rgtm1Wjl/YckNarl
Status
LM| (Live Animal)
Availability Level3
Pricing
Last Update Date 2018/1/25
Analysis Data
  • Description
  • Genes &
    alleles
  • Phenotype
  • Health &
    husbandry
  • References
  • Specific Term
    and Conditions
  • Construct map
Species laboratory mouse
Strain Type MSK (mutant stock),CON (congenic strain)
Mutant Type TM (Target Mutation)
Other Names
Background Strain NOD.CB17-Prkdcscid/JNarl
Strain Description
1. ASID was produced by breeding NOD.CB17-Prkdcscid/JNarl (RMRC No.12003) with B6.129S4-Il2rgtm1Wjl/J carried X-linked Il2rg mutation. The resulting male mice heterozygous for the Prkdcscid allele and Il2rgtm1Wjl allele were backcrossed to female NOD.CB17-Prkdcscid/JNarl for ten generation.
2.  ASID is viable, fertile, normal in size but deficient in immune cells, such as B cells, T cells, and NK cells.
3.  No antibody was detected in ASID mice after diphtheria immunization.
4. ASID mice are superior to traditional immunodeficient mice for human tumor transplantation.
Depositor
National Laboratory Animal Center, Narlabs / 國家實驗研究院國家實驗動物中心
Email
Allele Symbol Prkdcscid
Allele Name protein kinase, DNA activated, catalytic polypeptide; severe combined immunodeficiency
Allele Description A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon
Allele Symbol Il2rgtm1Wjl
Allele Name targeted mutation 1, Warren J Leonard
Allele Description A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein. 
Strain of Origin B6.129S4xNOD
Gene Symbol Prkdc
Gene Name protein kinase, DNA activated, catalytic polypeptide
Chromosome 16
Gene Symbol Il2rg
Gene Name interleukin 2 receptor, gamma chain
Chromosome X
Genotyping Method            
Genotyping NLAC            
Research Application
Cancer Immunology and Inflammation
Diabetes and Obesity Virology
Construction Technologies No
Animal Health Reports
Colony Maintenance
Breeding & Husbandry
Colony Maintenance
Mating System
homo x hetero/hemi
References No

Specific Terms of Use
無特別規定
寄存者對於分讓申請人使用本材料所獲得之研究成果,不主張任何專利、智慧財產權及其他財產權
DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of BIOLOGICAL RESOURCE.
Construct Map